A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis
| Autor: | Takeshi Sugimoto, Yoshiro Yasutomo, Koichi Yokono, Katsuhito Nishiyama, Shinya Ohata, Tomofumi Takayoshi, Takashi Arai, Kenta Hara |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
Tuberculosis Phagocytosis Hepatosplenomegaly Case Report 030204 cardiovascular system & hematology Microbiology Sputum culture Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Pulmonary tuberculosis hemic and lymphatic diseases Medicine 030212 general & internal medicine medicine.diagnostic_test biology business.industry medicine.disease biology.organism_classification Infectious Diseases medicine.anatomical_structure Immunology Parasitology Bone marrow medicine.symptom business Hepatic dysfunction |
| Zdroj: | Oxford Medical Case Reports |
| ISSN: | 2053-8855 |
| Popis: | An 80-year-old woman was admitted with continuous fever, hepatic dysfunction and cytopaenia. The presence of hepatosplenomegaly, hyperferritinaemia, hypofibrinogenaemia and phagocytosis by macrophages in the bone marrow was consistent with a diagnosis of haemophagocytic lymphohistiocytosis (HLH). We suspected that HLH was induced by pre-existing tuberculosis, and antitubercular agents were started. Positive nucleic acid amplification and sputum culture for Mycobacterium tuberculosis resulted in a diagnosis of pulmonary tuberculosis. The patient improved with three months of treatment. In this patient, manifestations of HLH preceded those of pulmonary tuberculosis. A diagnosis of HLH should increase suspicion of disseminated tuberculosis and thus contribute to early detection. |
| Databáze: | OpenAIRE |
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