The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatment

Autor: Lezhen Huang, Fengfeng Xie, Fang Chen, Shaowen Zhong, Jia-Huai Wen, Liping Ren, Feng Ye, Dan Liu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
surgical intervention
Antineoplastic Agents
Breast Neoplasms
lcsh:RC254-282
Disease-Free Survival
Metastasis
03 medical and health sciences
0302 clinical medicine
Breast cancer
breast cancer
Internal medicine
medicine
Hepatectomy
Humans
Radiology
Nuclear Medicine and imaging
Original Research
Retrospective Studies
Salvage Therapy
Radiofrequency Ablation
Univariate analysis
business.industry
Proportional hazards model
Liver Neoplasms
Case-control study
Clinical Cancer Research
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Metastatic breast cancer
Progression-Free Survival
liver metastasis
030104 developmental biology
Case-Control Studies
030220 oncology & carcinogenesis
Regression Analysis
Female
business
Cohort study
Zdroj: Cancer Medicine, Vol 9, Iss 13, Pp 4656-4666 (2020)
Cancer Medicine
ISSN: 2045-7634
Popis: Background Combined with systemic therapy, the surgical intervention for breast cancer liver metastases (BCLM) is increasingly accepted but lacks convincing evidence. The aim of this study was to evaluate the disease control efficacy of hepatic surgery in isolated BCLM patients. Methods Between 2012 and 2017, metastatic breast cancer patients with isolated liver metastasis and regular follow‐up were identified. Cohort design was conducted to compare the progression‐free survival (PFS) between the surgical and nonsurgical BCLM patients. Univariate analysis and multivariate Cox regression survival analyses were performed to identify significant prognostic factors. Result In all, 148 isolated BCLM patients were enrolled and 95 participants received hepatic surgery for metastatic lesions. With median follow‐up of 36.47 months, there was no significant difference between hepatic surgical group and nonsurgical group for PFS (median PFS: 11.17 months vs 10.10 m, P = .092). Based on the multivariate analysis, the disease‐free interval (DFI) was an independent prognostic factor for isolated BCLM patients. Among the surgical group, BCLM patients who had ideal response after first salvage systemic treatment experienced the best long‐term survival (median PFS: 14.20 months). Conclusion For isolated BCLM patients with ideal response in first‐line medical treatment, surgical intervention (hepatectomy, radiofrequency ablation) combining with systemic treatment could bring improved progression‐free survival compared to sole systemic treatment, indicating that hepatic surgery may be considered as a therapeutic choice for selected isolated BCLM patients in clinical practice.
In highly selected patients, surgical intervention (hepatectomy, radiofrequency ablation) combining with systemic treatment could bring improved progression‐free survival compared to sole systemic treatment, indicating that hepatic surgery may be considered as a therapeutic choice for selected isolated BCLM patients in clinical practice.
Databáze: OpenAIRE
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