Hyperphosphatemia, hypocalcemia and increased serum potassium concentration as distinctive features of early hypomagnesemia in magnesium-deprived mice
| Autor: | Jason M. Dey, Bernardo Ortega, Jacob R MacWilliams, Valerie B Courtright |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Clinical Biochemistry Parathyroid hormone Biochemistry Hypocalciuria Hypomagnesemia Phosphates Excretion chemistry.chemical_compound Hyperphosphatemia Internal medicine Magnesium deficiency (medicine) medicine Animals Magnesium Molecular Biology Aldosterone Hypocalcemia Chemistry Body Weight Water-Electrolyte Balance medicine.disease Hyperphosphaturia Adaptation Physiological Mice Inbred C57BL Disease Models Animal Fibroblast Growth Factor-23 Endocrinology Potassium Hyperkalemia Calcium medicine.symptom Magnesium Deficiency Biomarkers |
| Zdroj: | Magnesium research. 28(4) |
| ISSN: | 1952-4021 |
| Popis: | Magnesium-deficient patients show dysfunctional calcium (Ca(2+)) metabolism due to defective parathyroid hormone (PTH) secretion. In mice and rats, long-term magnesium (Mg(2+)) deprivation causes hyperphosphaturia and increases fibroblast growth factor 23 (FGF23) secretion, despite normal serum phosphate (Pi) and Ca(2+). Electrolyte disturbances during early hypomagnesemia may explain the response of mice to long-term Mg(2+) deprivation, but our knowledge of electrolyte homeostasis during this stage is limited. This study compares the effect of both short- and long-term Mg(2+) restriction on the electrolyte balance in mice. Mice were fed control or Mg(2+)-deficient diets for one to three days, one week, or three weeks. Prior to killing the mice, urine was collected over 24 h using metabolic cages. Within 24 h of Mg(2+) deprivation, hypomagnesemia, hypocalcemia and hyperphosphatemia developed, and after three days of Mg(2+) deprivation, serum potassium (K(+)) was increased. These changes were accompanied by a reduction in urinary volume, hyperphosphaturia, hypocalciuria and decreased Mg(2+), sodium (Na(+)) and K(+) excretion. Surprisingly, after one week of Mg(2+) deprivation, serum K(+), Pi and Ca(2+) had normalized, showing that mineral homeostasis is most affected during early hypomagnesemia. Serum Pi and K(+) are known to stimulate secretion of FGF23 and aldosterone, which are usually elevated during Mg(2+) deficiency. Thus, the hyperphosphatemia and increased serum K(+) concentration observed during short-term Mg(2+) deprivation may help our understanding of adaptation to chronic Mg(2+) deficiency. |
| Databáze: | OpenAIRE |
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