Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: The EPIC study

Autor: Elio Riboli, Isabelle Romieu, Vasiliki Benetou, Françoise Clavel-Chapelon, Eva Lundin, Maria Luisa Redondo, Naomi E. Allen, Veronika Fedirko, Rudolf Kaaks, Carlotta Sacerdote, Antonia Trichopoulou, Annekatrin Lukanova, Annika Idahl, Marie-Christine Boutron-Ruault, H. Bas Bueno-de-Mesquita, Teresa Norat, Anne Tjønneland, Laure Dossus, P. Hainaut, Birgit Teucher, Catalina Bonet, Jone M. Altzibar, Heiner Boeing, Nathalie Chabbert-Buffet, Eva Ardanaz, Dora Romaguera, Rosario Tumino, Esther Molina-Montes, Nicholas J. Wareham, María Dolores Chirlaque, Sabina Rinaldi, Susen Becker, Petra H.M. Peeters, Fränzel J.B. Van Duijnhoven, Anja Olsen, N. Charlotte Onland-Moret, Sabina Sieri, Elisavet Valanou, Kim Overvad, Domenico Palli, Jenny Chang-Claude, Rocco Galasso, Kay-Tee Khaw, Tobias Pischon
Přispěvatelé: University of Groningen
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Dossus, L, Becker, S, Rinaldi, S, Lukanova, A, Tjønneland, A, Olsen, A, Overvad, K, Chabbert-Buffet, N, Boutron-Ruault, M-C, Clavel-Chapelon, F, Teucher, B, Chang-Claude, J, Pischon, T, Boeing, H, Trichopoulou, A, Benetou, V, Valanou, E, Palli, D, Sieri, S, Tumino, R, Sacerdote, C, Galasso, R, Redondo, M-L, Bonet Bonet, C, Molina-Montes, E, Altzibar, J M, Chirlaque, M-D, Ardanaz, E, Bueno-de-Mesquita, H B, van Duijnhoven, F J B, Peeters, P H M, Onland-Moret, N C, Lundin, E, Idahl, A, Khaw, K-T, Wareham, N, Allen, N, Romieu, I, Fedirko, V, Hainaut, P, Romaguera, D, Norat, T, Riboli, E & Kaaks, R 2011, ' Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: The EPIC study ', International Journal of Cancer, vol. 129, no. 8, pp. 2032-2037 . https://doi.org/10.1002/ijc.25840
International Journal of Cancer, 129(8), 2032-2037. Wiley
ISSN: 0020-7136
DOI: 10.1002/ijc.25840
Popis: Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-alpha (TNF-alpha), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-alpha and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-alpha (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, P(trend) = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, P(trend) = 0.07) and sTNFR2 (OR: 1.53, 95% CI: 0.92-2.55, P(trend) = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-alpha and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.
Databáze: OpenAIRE
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