Codelivery of Antigens and Adjuvant in Polymeric Nanoparticles Coated With Native Parasite Membranes Induces Protective Mucosal Immunity Against Giardia lamblia
| Autor: | Zhou, Jiarong, Miyamoto, Yukiko, Ihara, Sozaburo, Kroll, Ashley V, Nieskens, Noelle, Tran, Vivien N, Hanson, Elaine M, Fang, Ronnie H, Zhang, Liangfang, Eckmann, Lars |
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| Rok vydání: | 2022 |
| Předmět: |
Giardiasis
Bioengineering Medical and Health Sciences Microbiology Vaccine Related protozoa Mice Adjuvants Immunologic Immunologic biomimetic nanoparticle Biodefense parasitic diseases Nanotechnology Animals Humans Immunology and Allergy Parasites Adjuvants Immunity Mucosal Mucosal Prevention Brief Report Immunity Biological Sciences Foodborne Illness multivalent vaccine intestinal mucosa Emerging Infectious Diseases Infectious Diseases nanovaccine Nanoparticles Immunization Giardia lamblia Digestive Diseases Infection |
| Zdroj: | J Infect Dis The Journal of infectious diseases, vol 226, iss 2 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | The protozoan pathogen Giardia lamblia is an important worldwide cause of diarrheal disease and malabsorption. Infection is managed with antimicrobials, although drug resistance and treatment failures are a clinical challenge. Prior infection provides significant protection, yet a human vaccine has not been realized. Individual antigens can elicit partial protection in experimental models, but protection is weaker than after prior infection. Here, we developed a multivalent nanovaccine by coating membranes derived from the parasite onto uniform and stable polymeric nanoparticles loaded with a mucosal adjuvant. Intranasal immunization with the nanovaccine induced adaptive immunity and effectively protected mice from G. lamblia infection. |
| Databáze: | OpenAIRE |
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