Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1
| Autor: | Kazunori Kusumoto, Yoko Kubuki, Kazuo Kuroki, Kenji Nagata, Kazuya Shimoda, Tadashi Miike, Tomonori Hidaka, Toshimasa Ochiai, Shojiro Yamamoto, Mitsue Sueta, Junya Kato, Shuichi Hirono, Yuri Yamada, Kotaro Shide, Naoto Komada, Yoshinori Ozono, Mai Tsuchimochi, Yoshihiro Tahara, Hisayoshi Iwakiri, Yuka Takaishi, Satoru Hasuike, Masafumi Shigehira, Kenichi Nakamura |
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| Rok vydání: | 2017 |
| Předmět: |
Ledipasvir
medicine.medical_specialty Hepatology Sofosbuvir business.industry Hepatitis C medicine.disease DIRECT ACTING ANTIVIRALS Chronic hepatitis C Direct acting antivirals 03 medical and health sciences chemistry.chemical_compound Sustained virological response 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Internal medicine Genotype medicine Retrospective Cohort Study 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | World Journal of Hepatology |
| ISSN: | 1948-5182 |
| Popis: | AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir (SOF) and ledipasvir (LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype 1. METHODS This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects (AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger (aged < 75 years) and elderly (aged ≥ 75 years). Virological data and AEs were analyzed by age group. RESULTS The sustained virological response (SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy. |
| Databáze: | OpenAIRE |
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