HIV, Antiretroviral Therapy and Metabolic Alterations: A Review
| Autor: | Safeera Khan, Mehwish Javed, Tun Zan Maung, Evelyn E Inga, Huseyin Ekin Ergin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
hypertension
antiretroviral Human immunodeficiency virus (HIV) Infectious Disease hiv 030204 cardiovascular system & hematology medicine.disease_cause Bioinformatics metabolic syndrome 03 medical and health sciences 0302 clinical medicine Insulin resistance insulin resistance medicine Internal Medicine Metabolic Problems business.industry Hypertriglyceridemia dyslipidemia General Engineering medicine.disease Antiretroviral therapy HIV/AIDS Metabolic syndrome business 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | The introduction of antiretroviral therapy (ART) has caused some metabolic problems to people who suffer from HIV. ART probably is not the sole reason for these metabolic disorders. Most likely, HIV itself affects the metabolism as well. We conducted research to find the prevalence of the different types of metabolic disorders among HIV(+) patients. Female gender, high BMI, and older age are among the risk factors for the occurrence of metabolic disorders. Regarding dyslipidemia, hypertriglyceridemia and low high-density lipoproteins (HDLs) are the most common types of dyslipidemia in the studies we included. Protease inhibitors (PIs) are widely known as the most common class of antiretroviral drugs that cause metabolic disorders, and some studies in our review also demonstrated this knowledge. In our review, we concluded that HIV and ART concurrently alter the metabolism, but further research is required about this substantial topic. |
| Databáze: | OpenAIRE |
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