Efficacy and Safety of Albendazole and High-Dose Ivermectin Coadministration in School-Aged Children Infected With Trichuris trichiura in Honduras: A Randomized Controlled Trial
| Autor: | José Antonio Gabrie, Pamela Cajal, Laura Ceballos, Alejandro J. Krolewiecki, María Mercedes Rueda, Rubén O. Cimino, Marisa Juarez, Luis Alvarez, Maritza Canales, Carol Anahelka Rodríguez, Andrés Escalada, Carlos Edmundo Lanusse, Gabriela Matamoros, Ana Sanchez, Helena Martí-Soler |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) ANTHELMINTIC medicine.medical_specialty 030106 microbiology Albendazole Gastroenterology law.invention 03 medical and health sciences purl.org/becyt/ford/3.3 [https] 0302 clinical medicine Ivermectin Randomized controlled trial law Internal medicine medicine Animals Humans 030212 general & internal medicine Adverse effect Child Anthelmintics School age child Schools biology business.industry biology.organism_classification TRICHURIS Trichuris trichiura Infections Clinical trial Infectious Diseases Trichuris Honduras Trichuris trichiura purl.org/becyt/ford/3 [https] ALBENDAZOLE IVERMECTIN business medicine.drug |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 1537-6591 |
| Popis: | Background: The efficacy of currently available anthelminthics against Trichuris trichiura infections is significatively lower than for other soil-transmitted helminths (STH). The combination of ivermectin (IVM) and albendazole (ALB) has shown significant improvements in efficacy.Methods: Safety and efficacy randomized controlled clinical trial comparing 3 experimental regimens against ALB monotherapy for the treatment of T. trichiura infections in northern Honduras. Infected children were randomized to one of the following treatments: (Arm 1) single-dose ALB 400 mg; (Arm 2) single-dose ALB 400 mg/IVM 600 μg/kg; (Arm 3) ALB 400 mg for 3 consecutive days; or (Arm 4) ALB 400 mg/IVM 600 μg/kg for 3 consecutive days. Efficacy was measured through egg reduction rate (ERR) and cure rate (CR), both assessed 14-21 days after treatment using the Kato-Katz method. Safety was evaluated by analyzing the frequency and severity of adverse events.Results: A total of 176 children were randomized to one of the 4 treatment arms, 117 completed treatment and follow-up. The ERR for Arms 1 to 4 were: 47.7%, 96.7%, 72.1% and 100%, respectively; with p-values |
| Databáze: | OpenAIRE |
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