Inhibition of beta-glucuronidase by casein hydrolysate formula
| Autor: | Bill L. Kreamer, Glenn R. Gourley, Monika Cohnen |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Meconium
medicine.medical_specialty Protein Hydrolysates Hydrolysate Casein hydrolysate Feces Internal medicine Casein medicine Animals Humans Enzyme Inhibitors Glucuronidase chemistry.chemical_classification Milk Human business.industry Gastroenterology Infant Newborn Caseins Infant nutrition Jaundice Hydrogen-Ion Concentration Endocrinology Enzyme Infant formula chemistry Liver Pediatrics Perinatology and Child Health Cattle Infant Food medicine.symptom business |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 25(3) |
| ISSN: | 0277-2116 |
| Popis: | A casein hydrolysate infant formula has been shown to be associated with lower levels of neonatal jaundice than are standard infant formulas. Because beta-glucuronidase is related to neonatal jaundice, this study examined the effect of a casein hydrolysate formula on beta-glucuronidase.Beta-glucuronidase activity was measured with or without added dietary components. The beta-glucuronidase sources used were meconium, breast milk, and the purified bovine liver enzyme. The dietary components assayed for their effect on beta-glucuronidase activity included casein hydrolysate formula (Nutramigen), whey-predominant formula (Enfamil), breast milk; enzymatically hydrolyzed casein, and other constituents of the casein hydrolysate formula. Stool samples of 6-day-old infants, who were exclusively fed one of the two formulas or breast milk, were also assayed for inhibition of beta-glucuronidase.Only Nutramigen, enzymatically hydrolyzed casein, and stool from Nutramigen-fed infants consistently demonstrated significant inhibition of beta-glucuronidase activity, ranging from 45% to 85% of that in controls. The inhibition of beta-glucuronidase in purified bovine liver demonstrates a dose response in a pH range from 4 to 7.3.Hydrolyzed casein contains a beta-glucuronidase inhibitor that, in casein hydrolysate-fed infants, persists after passage through the digestive tract. These data are consistent with the possibility that inhibition of beta-glucuronidase is a mechanism by which infants fed casein hydrolysate have lower jaundice levels than infants fed routine formulas or breast milk. Further study of this mechanism is needed. |
| Databáze: | OpenAIRE |
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