Interrater reliability of the new criteria for behavioral variant frontotemporal dementia
| Autor: | Zachary A. Miller, Lovingly Quitania Park, Jayne Hagen, Edmond Teng, David P. Salmon, Leonel T. Takada, Katya Rascovsky, Amanda K. LaMarre, Maria Carmela Tartaglia, Bradford C. Dickerson, David C. Perry, Bruce L. Miller, Sarah E Tomaszewski Farias, Berneet Kaur, Mario F. Mendez, Kimiko Domoto-Reilly, Georges Naasan, Parnian Toofanian, Douglas Galasko, Scott M. McGinnis, Gail A. Kang, Po-Heng Tsai, Joel H. Kramer, Robert Laforce, Alan Bostrom, John M Olichney, Sarah Wilkins, Sharon J. Sha |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Aging Clinical Sciences and over Neuropsychological Tests Neurodegenerative Alzheimer's Disease Article Developmental psychology Primary progressive aphasia Rare Diseases Physicians medicine 80 and over Acquired Cognitive Impairment Dementia Humans Psychology Apathy Single-Blind Method Medical diagnosis Aged Aged 80 and over Observer Variation Neurology & Neurosurgery Neuropsychology Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Middle Aged medicine.disease Brain Disorders Inter-rater reliability Frontotemporal Dementia (FTD) Frontotemporal Dementia Neurological Female Cognitive Sciences Neurology (clinical) medicine.symptom Alzheimer's disease Clinical psychology Frontotemporal dementia |
| Zdroj: | Neurology, vol 80, iss 21 |
| Popis: | Objective: To evaluate the interrater reliability of the new International Behavioural Variant FTD Criteria Consortium (FTDC) criteria for behavioral variant frontotemporal dementia (bvFTD). Methods: Twenty standardized clinical case modules were developed for patients with a range of neurodegenerative diagnoses, including bvFTD, primary progressive aphasia (nonfluent, semantic, and logopenic variant), Alzheimer disease, and Lewy body dementia. Eighteen blinded raters reviewed the modules and 1) rated the presence or absence of core diagnostic features for the FTDC criteria, and 2) provided an overall diagnostic rating. Interrater reliability was determined by κ statistics for multiple raters with categorical ratings. Results: The mean κ value for diagnostic agreement was 0.81 for possible bvFTD and 0.82 for probable bvFTD (“almost perfect agreement”). Interrater reliability for 4 of the 6 core features had “substantial” agreement (behavioral disinhibition, perseverative/compulsive, sympathy/empathy, hyperorality; κ = 0.61–0.80), whereas 2 had “moderate” agreement (apathy/inertia, neuropsychological; κ = 0.41–0.6). Clinician years of experience did not significantly influence rater accuracy. Conclusions: The FTDC criteria show promise for improving the diagnostic accuracy and reliability of clinicians and researchers. As disease-altering therapies are developed, accurate differential diagnosis between bvFTD and other neurodegenerative diseases will become increasingly important. |
| Databáze: | OpenAIRE |
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