Breast carcinomas with hyperprolactinemia at the time of diagnosis-clinico-biological association
| Autor: | J. I. Arias, A. Ruibal, M. Herranz, M. Pombo, P. Menendez-Rodriguez |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
medicine.medical_specialty Endocrinology Diabetes and Metabolism Estrogen receptor Breast Neoplasms Endocrinology Breast cancer Internal medicine Progesterone receptor Biomarkers Tumor medicine Humans Lymph node Aged Aged 80 and over business.industry Carcinoma Ductal Breast Age Factors Obstetrics and Gynecology Distant metastasis Middle Aged Prognosis medicine.disease Prolactin Hyperprolactinemia Androgen receptor medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Receptors Estrogen Receptors Androgen Immunohistochemistry Female Receptors Progesterone business |
| Zdroj: | Gynecological Endocrinology. 28:278-281 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | To analyse association between preoperative hyperprolactinemia serum levels and clinical and biological features of breast tumors.Serum levels of prolactin were measured in 253 women with invasive breast cancer. Clinical and biological parameters analysed were age, size, lymph node involvement, distant metastasis and immunohistochemical expression of estrogen receptor, progesterone receptor, androgen receptor, bcl-2, p53 and Ki67.In ductal carcinomas hyperprolactinemia were associated with high age (p = 0.017), and with bcl-2 + + + expression (p = 0.017). Furthermore, serum prolactin values were significantly higher in bcl-2 +++ cases vs negative (p = 0.029); the same happened when we considered the positivity threshold of 25 ng/mL (p = 0.015).Is possible to detect in 6% of infiltrating ductal breast carcinomas hyperprolactinemia (25 ng/mL), being associated only with increasing age, but not with other clinical or biological factors; and 2) the most surprising data was the association between prolactinemia (qualitative (25 ng/mL) and quantitative) and intense bcl-2 tissue expression, which suggests that, probably, this (prolactinemia) is not a sign of worse prognosis and evolution. |
| Databáze: | OpenAIRE |
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