Nitrous Oxide for Early Analgesia in the Emergency Setting: A Randomized, Double-blind Multicenter Prehospital Trial
| Autor: | Nathalie Lecoules, Manon Durand-Béchu, Patrice Marco, Vincent Bounes, Georges Siksik, Sébastien Couarraze, Jean-Louis Ducassé, Baptiste Vallé, Thierry Lacombe |
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| Přispěvatelé: | Education, Formation, Travail, Savoirs (EFTS), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA)-Université Toulouse - Jean Jaurès (UT2J), CHU de Toulouse, Pole d'anesthésie Réanimation, Hôpital Paule de Viguier, Toulouse F-31059, France, CHU Toulouse [Toulouse] |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pain relief Nitrous Oxide Double blind 03 medical and health sciences 0302 clinical medicine Double-Blind Method Medicine Humans Pain Management In patient 030212 general & internal medicine Prospective Studies Acute pain ComputingMilieux_MISCELLANEOUS Aged Pain Measurement Gynecology business.industry Moderate pain 030208 emergency & critical care medicine General Medicine Pain management Middle Aged Acute Pain 3. Good health Surgery Oxygen Treatment Outcome Multicenter study Patient Satisfaction Emergency Medicine Female Analgesia business Acute trauma Emergency Service Hospital [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Academic Emergency Medicine Academic Emergency Medicine, Wiley, 2013, 20 (2), pp.178-184. ⟨10.1111/acem.12072⟩ |
| ISSN: | 1069-6563 |
| Popis: | Objectives Although 50% nitrous oxide (N2O) and oxygen is a widely used treatment, its efficacy had never been evaluated in the prehospital setting. The objective of this study was to demonstrate the efficacy of premixed N2O and oxygen in patients with out-of-hospital moderate traumatic acute pain. Methods This prospective, randomized, multicenter, double-blind trial enrolled patients with acute moderate pain (numeric rating scale [NRS] score between 4 and 6 out of 10) caused by trauma. Patients were assigned to receive either 50/50 N2O and oxygen 9 L/min (N2O group) or medical air (MA) 9 L/min (MA group), in ambulances from two nurse-staffed fire department centers. After the first 15 minutes, every patient received N2O and oxygen. The primary endpoint was pain relief at 15 minutes (T15), defined as a NRS ≤ 3 of 10. The NRS was measured every 5 minutes. Secondary endpoints were treatment safety and adverse events, time to analgesia, and patient and investigator satisfaction with analgesia. Results Sixty patients were included with no differences between groups in age (median = 34 years, interquartile range [IQR] = 23 to 53 years), sex (37 males, 66%), and initial median NRS of 6 (IQR = 5 to 6). At T15, 67% of the patients in the N2O group had an NRS score of 3 or lower versus 27% of those in the MA group (delta = 40%, 95% confidence interval [CI] = 17% to 63%; p |
| Databáze: | OpenAIRE |
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