Fluoxetine versus amitriptyline in the treatment of major depression: a multicenter trial
| Autor: | Mary E. Sayler, Charles M. Beasley, Janet H. Potvin |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Serotonin uptake Nausea medicine.drug_class Amitriptyline Tricyclic antidepressant Orthostatic vital signs Double-Blind Method Multicenter trial Fluoxetine medicine Humans Pharmacology (medical) Aged Depressive Disorder business.industry Middle Aged medicine.disease Psychiatry and Mental health Treatment Outcome Anesthesia Major depressive disorder Female medicine.symptom business medicine.drug |
| Zdroj: | International clinical psychopharmacology. 8(3) |
| ISSN: | 0268-1315 |
| Popis: | Fluoxetine, a serotonin uptake inhibitor, and amitriptyline, a tricyclic antidepressant, were compared in a 5-week, multicenter, double-blind, randomized trial in 136 out-patient men and women, aged 21-70 years, with major depressive disorder. Overall efficacy was comparable with fluoxetine and amitriptyline [Hamilton 21-Item Rating Scale for Depression (HAM-D21), Raskin, Covi, Clinical Global Impressions-Severity and -Improvement, Patient's Global Impressions]. Mean +/- standard deviation decreases in HAM-D21 total score were 12.9 +/- 9.9 and 11.6 +/- 10.3 (p = 0.423), respectively. Response rates (> or = 50% decrease in HAM-D21 total score) for patients treated > or = 4 weeks were 46.7% and 66.0% (p = 0.039) and remission rates (HAM-D21 total score < or = 7) were 18.3% and 28.3% (p = 0.209), respectively. Response and remission rates for all patients were comparable with fluoxetine and amitriptyline. Study completions were higher with fluoxetine than amitriptyline (87.7% vs 66.2%; p = 0.003). Discontinuations for adverse events were higher with amitriptyline than fluoxetine (22.5% vs 6.2%; p = 0.007). More treatment-emergent nausea and insomnia were reported with fluoxetine (p < or = 0.05); more anticholinergic and orthostatic events and weight gain were reported with amitriptyline (p < or = 0.05). Statistically, but not clinically, significant changes were observed in vital signs. Both fluoxetine and amitriptyline were effective treatments for out-patients with major depressive disorder. Fluoxetine had a more favorable safety profile than amitriptyline. |
| Databáze: | OpenAIRE |
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