The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
| Autor: | Calliandra Maria de Souza Silva, Rafael Martins de Morais, Jamila Reis de Oliveira, Alaor Barra Sobrinho, Otávio de Toledo Nóbrega, Izabel Cristina Rodrigues da Silva |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Review Article lcsh:Diseases of the endocrine glands. Clinical endocrinology Papillary thyroid cancer Cancer pathogenesis 03 medical and health sciences 0302 clinical medicine Endocrinology Chromosome 19 medicine Transmembrane glycoprotein Epigenetics Gene health care economics and organizations lcsh:RC648-665 Endocrine and Autonomic Systems business.industry medicine.disease Solute carrier family 030104 developmental biology Tireóide - câncer 030220 oncology & carcinogenesis Thyroid malignancy Cancer research business |
| Zdroj: | International Journal of Endocrinology Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB International Journal of Endocrinology, Vol 2018 (2018) |
| ISSN: | 1687-8345 1687-8337 |
| Popis: | Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer. |
| Databáze: | OpenAIRE |
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