Pluripotent stem cells to hepatocytes, the journey so far
| Autor: | Jyoti Nanda, James A. Ross, Anwar Azad Palakkan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
General Neuroscience Liver failure Review General Medicine Biology Regenerative medicine Molecular medicine General Biochemistry Genetics and Molecular Biology Cell biology 03 medical and health sciences 030104 developmental biology Genome editing Journal Article General Pharmacology Toxicology and Pharmaceutics Induced pluripotent stem cell Reprogramming |
| Zdroj: | Palakkan, A A, Nanda, J & Ross, J A 2017, ' Pluripotent stem cells to hepatocytes, the journey so far ', Biomedical Reports, vol. 6, no. 4, pp. 367-373 . https://doi.org/10.3892/br.2017.867 |
| ISSN: | 2049-9442 2049-9434 |
| DOI: | 10.3892/br.2017.867 |
| Popis: | Over the past several years, there has been substantial progress in the field of regenerative medicine, which has enabled new possibilities for research and clinical application. For example, there are ongoing efforts directed at generating functional hepatocytes from adult-derived pluripotent cells for toxicity screening, generating disease models or, in the longer term, for the treatment of liver failure. In the present review, the authors summarise recent developments in regenerative medicine and pluripotent stem cells, the methods and tissues used for reprogramming and the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cells. In addition, the hepatic disease models developed using iPSC technologies are discussed, as well as the potential for gene editing. |
| Databáze: | OpenAIRE |
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