Infrequent Genetic Alterations of thePTEN/MMAC1Gene in Japanese Patients with Primary Cancers of the Breast, Lung, Pancreas, Kidney, and Ovary
| Autor: | Hiromitsu Yamakawa, Akihiko Suzuki, Shigefumi Fujimura, Shinji Uyeno, Masami Sato, Kazuhiko Orikasa, Akira Sakurada, Noriaki Ohuchi, Akira Horii, Tetsuya Ono |
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| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Lung Neoplasms Pancreatic disease Somatic cell Loss of Heterozygosity Breast Neoplasms Glioblastoma multiforme medicine.disease_cause Frameshift mutation Germline mutation Neoplasms medicine Humans PTEN Genes Tumor Suppressor Polymorphism Single-Stranded Conformational Ovarian Neoplasms Base Sequence biology Brain Neoplasms Somatic mutation DNA Neoplasm medicine.disease Candidate Tumor Suppressor Gene Kidney Neoplasms Pancreatic Neoplasms medicine.anatomical_structure Oncology Mutation biology.protein Cancer research Female Glioblastoma Pancreas Carcinogenesis Rapid Communication PTEN/MMAC1 gene |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| Popis: | In the present study, we searched for genetic alterations of the entire coding region of PTEN/MMACl, a recently isolated candidate tumor suppressor gene, in 178 specimens from Japanese patients with various malignant tumors by the polymerase chain reaction‐single strand conformation polymorphism method. The samples consisted of 11 glioblastoma multiformes (GBMs), 14 astrocytomas, 47 breast cancers, 25 non‐small cell lung cancers, 9 small cell lung cancers, 8 pancreatic cancers, 24 renal cell carcinomas, 20 ovarian cancers, and 20 metastatic lung tumors from various organs. Only one somatic frameshift mutation at codon 319 was observed in one (9%) of eleven GBMs. Our results suggest that mutation of the PTEN/MMAC1 gene does not play a major role in carcinogenesis, at least in the tumor types from Japanese patients analyzed in this study. |
| Databáze: | OpenAIRE |
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