IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy
| Autor: | Yaşar Zorlu, Irem Fatma Uludag, Feriha Ozkaya, Bedile Irem Tiftikcioglu, Güldal Kirkali, Tarik Duksal |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Interleukin-1beta Clinical Neurology Inflammation Gastroenterology Statistics Nonparametric Temporal lobe Epilepsy Young Adult Internal medicine medicine Humans Interleukin 6 Temporal lobe epilepsy IL-6 biology Interleukin-6 Electroencephalography General Medicine Middle Aged medicine.disease Lobe Serum cytokine Interleukin 1 Receptor Antagonist Protein medicine.anatomical_structure Interleukin 1 receptor antagonist Cytokine IL-1Ra Epilepsy Temporal Lobe Neurology IL-1β Anesthesia biology.protein Cytokines Female Neurology (clinical) medicine.symptom Psychology |
| Zdroj: | Seizure. 26:22-25 |
| ISSN: | 1059-1311 |
| DOI: | 10.1016/j.seizure.2015.01.009 |
| Popis: | © 2015 British Epilepsy Association.Purpose There is now extensive evidence to support the involvement of inflammation in the course of epileptic seizures. Seizure-induced changes in serum IL-1β, IL-6 and IL-1Ra levels are reported in several studies. Serum cytokine levels may also be disturbed in inter-ictal period due to seizure activity. Methods Twenty-one patients (12 women; mean age 35 ± 12.3) with temporal lobe epilepsy (TLE), 17 patients (8 women; mean age 31.8 ± 10.4) with extra-temporal lobe epilepsy (XLE) and 20 normal controls (10 women; mean age 35.6 ± 8.8) were included in the study. Serum levels of IL-1β, IL-6 and IL-1Ra of the TLE, XLE groups in inter-ictal period and of the normal control group were compared. Results All three cytokine levels are found to be significantly elevated in epilepsy patients when compared to controls (p < 0.05). In TLE group, IL-1β serum levels were significantly higher than in the XLE group (p < 0001). Conclusion The major findings in our study were increased levels of IL-1β, IL-6 and IL-1Ra in epileptic patients and high levels of IL-1β in TLE group. Our results support the existence of a chronic inflammatory state in epileptic patients. |
| Databáze: | OpenAIRE |
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