Adverse generational changes in obesity development converge at midlife without increased cardiometabolic risk
| Autor: | Martijn E T Dollé, W M Monique Verschuren, M. Liset Rietman, Ko Willems van Dijk, H. S. J. Picavet, Dorina Ibi, Jan B. van Klinken |
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| Přispěvatelé: | Laboratory Genetic Metabolic Diseases, Laboratory for General Clinical Chemistry, Amsterdam Gastroenterology Endocrinology Metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Waist Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Type 2 diabetes Overweight Body Mass Index Cohort Studies Young Adult Endocrinology Risk Factors Prevalence Humans Medicine Obesity Generalized estimating equation Nutrition and Dietetics business.industry Epidemiology/Genetics Middle Aged Anthropometry medicine.disease Diabetes Mellitus Type 2 Cardiovascular Diseases Life course approach Female Original Article Waist Circumference ORIGINAL ARTICLES medicine.symptom business Cohort study Demography |
| Zdroj: | Obesity, 29(11), 1925-1938. North American Association for the Study of Obesity Obesity, 29(11), 1925-1938. WILEY Obesity (Silver Spring, Md.) |
| ISSN: | 1930-7381 |
| Popis: | Objective Obesity is becoming a global public health problem, but it is unclear how it impacts different generations over the life course. Here, a descriptive analysis of the age‐related changes in anthropometric measures and related cardiometabolic risk factors across different generations was performed. Methods The development of anthropometric measures and related cardiometabolic risk factors was studied during 26 years of follow‐up in the Doetinchem Cohort Study (N = 6,314 at baseline). All analyses were stratified by sex and generation, i.e., 10‐year age groups (20‐29, 30‐39, 40‐49, and 50‐59 years) at baseline. Generalized estimating equations were used to test for generational differences. Results Weight, BMI, waist circumference, and prevalence of overweight and obesity were higher, in general, in the younger generations during the first 10 to 15 years of follow‐up. From age 50 to 59 years onward, these measures converged in all generations of men and women. Among cardiometabolic risk factors, only type 2 diabetes showed an unfavorable shift between the two oldest generations of men. Conclusions It was observed that, compared with the older generations, the younger generations had obesity at an earlier age but did not reach higher levels at midlife and beyond. This increased exposure to obesity was not (yet) associated with increased prevalence of cardiometabolic risk factors. |
| Databáze: | OpenAIRE |
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