Pharmacokinetics of theophylline after administration of suppositories formulation

Autor:	Hassan Y. Aboul-Enein, Laila I. Abou-Basha, A. Hamza, Lobna F. Wahman
Rok vydání:	2005
Předmět:	Adult Male Clinical Biochemistry Immunology Cmax Biological Availability Enzyme-Linked Immunosorbent Assay Suppository Pharmacology chemistry.chemical_compound Pharmacokinetics Theophylline Administration Rectal Immunology and Allergy Medicine Humans Child Cross-Over Studies business.industry Suppositories Crossover study Asthma Bioavailability Medical Laboratory Technology Piperazine chemistry Anesthesia Rectal administration Injections Intravenous business medicine.drug
Zdroj:	Journal of immunoassayimmunochemistry. 26(4)
ISSN:	1532-1819
Popis:	Asthma is a public health problem for developed countries. It attacks all age groups but often starts in childhood. Theophylline ethanoate of piperazine in a suppository form is one of the treatments of asthmatic children. The pharmacokinetics of theophylline were evaluated in 24 healthy male subjects after administration of theophylline ethanoate of piperazine suppositories (PR) (Minophylline 500 mg. Alexandria Co.) and single injection intravenous (IV) of theophylline ethanoate of piperazine (Minophylline ampoules 500 mg Alexandria Co.). The theophylline serum levels were determined by an ELISA method. Peak theophylline plasma concentration, Cmax, (mean +/- S.D) was 21.5 +/- 2.10 microg/mL & 14 +/- 0.90 microg/mL; AUC(0-t), values were 80.9 and 67. 4 microg x ml x hr for the reference IV preparation and suppositories, respectively. The median peak time, Tmax, was 0.5 hr for theophylline rectal administration. The above mentioned results demonstrate the possibilities of using theophylline (Minophylline Suppositories--500 mg Alexandria Co.) in asthmatic children in rural and desert areas away from health care personnel.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a0b24268e5a99b473492298802274f https://pubmed.ncbi.nlm.nih.gov/16153010 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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