Pathogenicity of Acyclovir-Resistant Herpes Simplex Virus Type 1 from an Immunodeficient Child
| Autor: | Paul M. Keller, M. H. St. Clair, Wilfert Cm, David Walter Barry, C. McLaren, Laura T. Gutman, C. D. Sibrack |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Simplexvirus Thymidine kinase activity food.ingredient Adenosine Deaminase viruses Microgram Acyclovir Mice Nude Virulence Biology medicine.disease_cause Mice food medicine Animals Humans Immunology and Allergy Mice Hairless Mice Inbred BALB C Severe combined immunodeficiency Idoxuridine Immunologic Deficiency Syndromes Infant Drug Resistance Microbial Herpes Simplex medicine.disease Virology Infectious Diseases Herpes simplex virus Thymidine kinase Female medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 146:673-682 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/146.5.673 |
| Popis: | Sequential isolates of herpes simplex virus type 1 (HSV-1) from a child with severe combined immunodeficiency were examined for sensitivity to acyclovir. Early intravenous courses of acyclovir resulted in dramatic clinical improvement and were associated with the isolation of sensitive strains of HSV-1 (ID50[dose inhibiting 50% of control plaques], 0.010-0.106 microgram/ml), whereas later recurrences following intravenous, oral, and ophthalmic therapy were characterized by low-grade chronic lesions (ID50, 1.04-9.43 microgram/ml) that were unresponsive to acyclovir despite serum levels of up to 10.45 microgram/ml. Diminished sensitivity was associated with reduced viral thymidine kinase activity, and linked resistance with idoxuridine was detected in the isolates from the patient's eye. Intracerebral and cutaneous snout inoculation of a resistant isolate into BALB/c, hairless, and athymic nude mice revealed a 100- to 1,000-fold decrease in virulence as compared with an early sensitive isolate. Acyclovir-resistant HSV-1 can emerge in certain clinical settings but may be associated with diminished virulence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|