A PstI polymorphism at 3′UTR of goat POU1F1 gene and its effect on cashmere production
| Autor: | J. H. Shu, Chuanying Pan, Xianyong Lan, Y. B. Zhang, Chuzhao Lei, Hong Chen, S. Q. Liu, Xinyu Wang |
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| Rok vydání: | 2008 |
| Předmět: |
Candidate gene
Genotype Population Locus (genetics) Biology Polymorphism Single Nucleotide PstI Genetics Animals Allele Deoxyribonucleases Type II Site-Specific education 3' Untranslated Regions Molecular Biology Allele frequency Gene education.field_of_study Polymorphism Genetic Goats Age Factors General Medicine biology.protein Transcription Factor Pit-1 Biomarkers Hair |
| Zdroj: | Molecular Biology Reports. 36:1371-1374 |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-008-9322-4 |
| Popis: | POU1F1 is a positive regulator for prolactin (PRL) whose metabolites may directly or indirectly affect some aspects of the hair growth cycle, therefore, POU1F1 gene is an important candidate gene for cashmere traits selection through marker-assisted selection (MAS). Hence, in this study, the PCR-RFLP method was applied to detect a T>C transition determining a PstI polymorphism at the 3′UTR of POU1F1 locus and evaluate its associations with cashmere traits in 847 Inner Mongolia White Cashmere goats. In the analyzed population, the allelic frequencies for the T and C alleles are 0.959 and 0.041, respectively and the genotypic frequencies are in Hardy-Weinberg equilibrium (P > 0.05). Moreover, significant statistical relationships between the PstI polymorphism of POU1F1 gene and goat cashmere yields were found (*P < 0.05). When compared with TC genotype, TT genotype was associated with superior cashmere yields in 2, 4, and 5 years old individuals, as well as with average cashmere yield. Hence, TT genotype is suggested to be a molecular marker for senior cashmere yield. |
| Databáze: | OpenAIRE |
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