The impact of a significant weight loss on inflammation assessed on DCE-MRI and static MRI in knee osteoarthritis: a prospective cohort study
| Autor: | Janus Damm Nybing, C.L. Daugaard, Marius Henriksen, Elisabeth Bandak, Morten Ilum Boesen, R.G.C. Riis, Henning Bliddal, Stine Hangaard |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Biomedical Engineering Contrast Media Osteoarthritis Overweight Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Weight loss Internal medicine Synovitis Weight Loss medicine Humans Orthopedics and Sports Medicine Prospective Studies skin and connective tissue diseases Prospective cohort study Aged 030203 arthritis & rheumatology business.industry Middle Aged Osteoarthritis Knee medicine.disease Magnetic Resonance Imaging 030104 developmental biology Knee pain Dynamic contrast-enhanced MRI Female medicine.symptom business Body mass index |
| Zdroj: | Osteoarthritis and Cartilage. 28:766-773 |
| ISSN: | 1063-4584 |
| Popis: | Summary Objective To study the impact of weight loss on inflammation in individuals with overweight and knee osteoarthritis (OA) using both static- and dynamic contrast-enhanced (DCE)-MRI and assess the association of these changes to pain. Design Individuals with overweight (BMI > 27) and knee OA were examined before and after a >5% weight loss over 8 weeks (ClinicalTrials.gov NCT02905864). Using 3-T MRI, inflammation was quantified from non-contrast enhanced static-MRI according to MOAKS and contrast enhanced static MRI according to BLOKS and 11-point whole-knee synovitis score. DCE-MRI was used to assess the inflammation in the infra patellar fat pad (IPFP). Pain was assessed using KOOS. Results Complete data were available in 117 participants with a mean age of 60 years, BMI of 35 kg/m2 and KOOS pain score of 64. Mean weight loss was 12 kg and KOOS pain was improved by 13 points at follow-up. Change in inflammation was not associated with weight loss in static MRI. None of the MRI variables correlated with the change in KOOS pain. Conclusion Weight loss did not induce a significant change in inflammation in individuals with overweight and OA. The significant clinical beneficial effect of weight loss on knee pain in individuals with overweight and knee OA seems uncoupled to changes in imaging markers of synovitis. |
| Databáze: | OpenAIRE |
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