In-vitro testing of RF-enabled low force mechanical thrombectomy for ischemic stroke

Autor:	David Cc Lam, Alexander Kn Lam, Matthew Ming Fai Yuen, John Ck. Kwok, Zhen Qin, Chi Hang Chon
Rok vydání:	2015
Předmět:	Stroke recurrence business.industry medicine.medical_treatment Stent Thrombosis medicine.disease Brain Ischemia Stroke Brain ischemia Mechanical thrombectomy Stenosis Treatment Outcome Ischemic stroke medicine Humans Stents business Thrombectomy Biomedical engineering
Zdroj:	EMBC
Popis:	Mechanical thrombectomy for ischemic stroke has high recanalization rate, long treatment time window and low hemorrhage risk. However, the clot engagement approach of caging the clot against the vessel wall can cause vessel stenosis and stroke recurrence. A device with reduced radial stenting force that reduces vessel wall friction would minimize stenosis and damage. The use of localized Radio Frequency (RF) to enable clot engagement and retrieval with minimal stenting force is explored in this study. New mechanical thrombectomy devices enabled with RF (Patent No.: US 62/172,043) were built and tested on human blood clots in vessels ex vivo. Test results showed that the RF-mechanical thrombectomy successfully and reproducibly captured and retrieved the clots without relying on stent caging of the clot against the vessel wall. Further work will be conducted on animals to compare vessel wall damage between conventional and RF-mechanical thrombectomy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309aeedea7e90ef0873a67e0685d05e1 https://doi.org/10.1109/embc.2015.7318618 Zobrazit plný text záznamu