Hirudin therapy during thrombolysis for venous thrombosis in heparin-induced thrombocytopenia
| Autor: | Alan Askenase, Emile R. Mohler, Richard L. Weiss, Muredach P. Reilly, Catherine M. Tuite, Michael C. Soulen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
0301 basic medicine
Hirudin Therapy business.industry medicine.drug_class medicine.medical_treatment Anticoagulant Hirudin Thrombolysis Heparin 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences Venous thrombosis 030104 developmental biology 0302 clinical medicine Heparin-induced thrombocytopenia Anesthesia Medicine Cardiology and Cardiovascular Medicine business medicine.drug Discovery and development of direct thrombin inhibitors |
| Zdroj: | Vascular Medicine. 5:239-242 |
| ISSN: | 1477-0377 1358-863X |
| Popis: | Heparin-induced thrombocytopenia (HIT) is the most common drug-related thrombocytopenia. Thromboembolic complications occur in approximately 50% of patients with HIT and result in limb amputation and death in up to 20% and 30% respectively. Because patients with a history of HIT may require future intravenous anticoagulation but have a high-risk of thromboembolism if re-challenged with heparin, alternative therapies are necessary when further anticoagulation is indicated. The use of direct thrombin inhibitors in HIT patients who also require thrombolytic therapy offers unique challenges to anticoagulant monitoring and safety. We present a case of progressive ileofemoral deep venous thrombosis in a patient with a history of HIT in order to review the combined use of hirudin and thrombolysis in this setting. |
| Databáze: | OpenAIRE |
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