K20 and ICO-10 monoclonal antibodies (gp120/200; Thy-1): immunophenotyping of human solid tumours
| Autor: | Kadagidze Zg, Tupitsyn Nn, Anatoly Ju. Baryshnikov, K. P. Kadyrov, Blinov Vm, Martine Amiot, A. Bernard, L. Boumsell |
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| Rok vydání: | 1990 |
| Předmět: |
Cancer Research
medicine.drug_class Biology Histogenesis Monoclonal antibody Neuroblastoma cell Immunophenotyping Antigen immune system diseases Antigens CD Receptors Very Late Antigen hemic and lymphatic diseases Neoplasms medicine Humans Solid tumour Antibodies Monoclonal hemic and immune systems respiratory system Molecular biology Phenotype Oncology Antigens Surface Immunohistochemistry Thy-1 Antigens Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ and Thy-1+; VLA-beta- and Thy-1+; VLA-beta- and Thy-1-. To a certain extent these groups have been shown to reflect tumour histogenesis: tumours of epithelial origin never expressed an ICO-10+, K20-phenotype while soft tissue sarcomas and neuroblastoma cells never expressed the beta-chain of VLA molecular complexes. |
| Databáze: | OpenAIRE |
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