Fatal enhanced respiratory syncytial virus disease in toddlers
| Autor: | Wes Gladwell, Diego R. Hijano, Alanna Wanek, Romina Libster, Jay K. Kolls, Luis M. Avendano, Eduardo Bergel, Robert V Blair, Damian Alvarez-Paggi, Gregory A. Prince, Joyce E. Johnson, Daniel Menendez, Luis Velozo, Derek Pociask, Mauricio T. Caballero, Paola X De la Iglesia Niveyro, Fernando P. Polack, Steven R. Kleeberger |
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| Rok vydání: | 2021 |
| Předmět: |
business.industry
viruses digestive oral and skin physiology Respiratory Syncytial Virus Infections General Medicine Disease Virus diseases Communicable Diseases Virology Virus Respiratory Syncytial Viruses Child Preschool Respiratory Syncytial Virus Vaccines Humans Medicine Respiratory system business |
| Zdroj: | Science Translational Medicine. 13 |
| ISSN: | 1946-6242 1946-6234 |
| Popis: | In 1967, two toddlers immunized with a formalin-inactivated vaccine against respiratory syncytial virus (FIRSV) in the United States died from enhanced RSV disease (ERD), a severe form of illness resulting from aberrant priming of the antiviral immune response during vaccination. Up to 80% of immunized children subsequently exposed to wild-type virus were hospitalized. These events hampered RSV vaccine development for decades. Here, we provide a characterization of the clinical, immunopathological, and transcriptional signature of fatal human ERD, outlining evidence for safety evaluation of RSV vaccines and a framework for understanding disease enhancement for pathogens in general. |
| Databáze: | OpenAIRE |
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