Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis
| Autor: | Ada Popolo, Rosanna Filosa, Rocco De Prisco, Carmela Saturnino, Giuseppina Tommonaro, Stefano Piotto, Erminia Bianchino, Anna Ramunno, Paolo Urbani, Aldo Pinto, Barbara Nicolaus |
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| Přispěvatelé: | Urbani, P, Ramunno, A, Filosa, Rosanna, Pinto, A, Popolo, A, Bianchino, E, Piotto, S, Saturnino, C, De Prisco, R, Nicolaus, B, Tommonaro, G. |
| Rok vydání: | 2008 |
| Předmět: |
Lipopolysaccharides
Diphenylpropionamide derivatives Antioxidant medicine.medical_treatment antioxidant activity brine shrimp test Pharmaceutical Science Antioxidants Analytical Chemistry Mice diphenylpropionamide derivative chemistry.chemical_compound Drug Discovery Organic chemistry Cytotoxic T cell ABTS Full Paper biology ROS J774.A1 macrophages antiproliferative activity QSAR analysis Chemistry (miscellaneous) Molecular Medicine Quantitative structure–activity relationship LPS Brine shrimp Nitric Oxide NO Catalysis lcsh:QD241-441 lcsh:Organic chemistry medicine Animals Physical and Theoretical Chemistry cytotoxic activity Cell Proliferation Macrophages Organic Chemistry synthetic diphenylpropionamide derivatives ROS NO LPS J774.A1 macrophages cytotoxic activity Brine Shrimp Test Computational Biology biology.organism_classification Amides In vitro synthetic diphenylpropionamide derivatives chemistry Cell culture Propionates Reactive Oxygen Species |
| Zdroj: | Molecules (Basel, Online) 13 (2008): 749–761. doi:10.3390/molecules13040749 info:cnr-pdr/source/autori:Urbani P.; Ramunno A.; Filosa R.; Pinto A.; Popolo A.; Bianchino E.; Piotto S.; Saturnino C.; De Prisco R.; Nicolaus B; Tommonaro G./titolo:Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis/doi:10.3390%2Fmolecules13040749/rivista:Molecules (Basel, Online)/anno:2008/pagina_da:749/pagina_a:761/intervallo_pagine:749–761/volume:13 Molecules; Volume 13; Issue 4; Pages: 749-761 Molecules Molecules, Vol 13, Iss 4, Pp 749-761 (2008) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules13040749 |
| Popis: | We report the synthesis, antioxidant and antiproliferative activity and a QSAR analysis of synthetic diphenylpropionamide derivatives. Synthesis of these compounds was achieved by direct condensation of 2,2- and 3,3-diphenylpropionic acid and appropriate amines using 1-propylphoshonic acid cyclic anhydride (PPAA) as catalyst. Compound structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in LPS stimulated J774.A1 macrophages. All compounds were tested for their effect on viability of cells and results demonstrated that they are not toxic towards the cell lines used. The cytotoxic activity of all compounds was evaluated by a Brine Shrimp Test. |
| Databáze: | OpenAIRE |
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