Apolipoprotein B gene polymorphisms in people in the East Mediterranean area of Turkey
| Autor: | Ugur Atik, H Pekdemir, Kahraman Tanriverdi, Bahadır Ercan, Ali Ünlü, Lülüfer Tamer, Nehir Sucu |
|---|---|
| Přispěvatelé: | Çukurova Üniversitesi |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Turkey Apolipoprotein B Arteriosclerosis Cholesterol VLDL Hypercholesterolemia Polymerase Chain Reaction chemistry.chemical_compound Rare Diseases Gene Frequency Humans Point Mutation East mediterranean Gene Apolipoproteins A Triglycerides Apolipoproteins B Molecular Epidemiology Polymorphism Genetic biology Mediterranean Region Cholesterol Point mutation Cholesterol HDL Cholesterol LDL General Medicine Middle Aged Molecular biology Causality chemistry Case-Control Studies Population Surveillance Low-density lipoprotein Healthy individuals Apolipoprotein B-100 biology.protein Female lipids (amino acids peptides and proteins) Lipoprotein |
| Zdroj: | Eastern Mediterranean Health Journal. 10:125-130 |
| ISSN: | 1687-1634 1020-3397 |
| DOI: | 10.26719/2004.10.1-2.125 |
| Popis: | Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding [Arg 3500 —-> [corrected] Gln, Arg 3500 —-> [corrected] Trp and Arg 3531 —-> [corrected] Cys]. We estimated the frequency of Apo B point mutations [codon 3500] C9774T [Arg 3500 —-> [corrected] Trp] and G9775A [Arg 3500 —-> [corrected] Gln] in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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