Effect of Hemodialysis on Oxygen-Hemoglobin Affinity in Chronic Uremics
| Autor: | Friedrich C. Luft, Mark O. Farber, Stuart A. Kleit, John R. Boykin, James J. Szwed |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Blood Glucose
Pulmonary and Respiratory Medicine medicine.medical_specialty Erythrocytes Anemia medicine.medical_treatment Bohr effect Critical Care and Intensive Care Medicine Hemoglobins Adenosine Triphosphate Renal Dialysis In vivo Internal medicine medicine Humans Glycolysis Pyruvates Dialysis Uremia Red Cell business.industry Acute Kidney Injury Carbon Dioxide Hydrogen-Ion Concentration Diphosphoglyceric Acids medicine.disease Oxygen Endocrinology Biochemistry Oxyhemoglobins Lactates Kidney Failure Chronic Hemoglobin Hemodialysis Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 66:278-281 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.66.3.278 |
| Popis: | P50, plasma pH, red cell pH, 2,3-DPG, ATP, lactate, pyruvate, and glycolytic rate were measured before and after hemodialysis in 25 patients on chronic hemodialysis. The prehemodialysis—resting 2,3-DPG level and P50 were elevated in accordance with the degree of anemia. The resting lactate and glycolytic rate were mildly elevated. Plasma and red cell pH increased significantly with dialysis. The in vivo P50 decreased significantly, whereas the in vitro P50, 2,3-DPG, and ATP levels remained constant. The fall in the in vivo P50 can be attributed entirely to the rise in red cell pH or Bohr effect. The decrease in the in vivo P50 during hemodialysis may transiently impair tissue oxygen delivery in these patients. Marked shifts in pH, especially into the alkalemic range, should be minimized, particularly in patients undergoing frequent or prolonged hemodialysis. |
| Databáze: | OpenAIRE |
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