Establishing the functional connectivity of the frontotemporal network in pre-attentive change detection with Transcranial Magnetic Stimulation and event-related optical signal
| Autor: | Chun-Yu Tse, Nathan A. Parks, Yang Wang, Winnie C.W. Chu, Long Yin Yip, Sandra S. M. Chan, Xue Zhen Xiao, Sebastiaan F. W. Neggers, Troby Ka Yan Lui |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Neurology Adolescent Computer science medicine.medical_treatment Cognitive Neuroscience Mismatch negativity Stimulus (physiology) Event-related optical signal Cognitive neuroscience behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences Functional connectivity Young Adult 0302 clinical medicine Frontotemporal network Neural Pathways medicine Premovement neuronal activity Humans 0501 psychology and cognitive sciences Attention Evoked Potentials Temporal cortex MMN Brain Mapping Sensory memory 05 social sciences Optical Imaging EROS Transcranial Magnetic Stimulation Temporal Lobe Frontal Lobe Transcranial magnetic stimulation TMS Change detection Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage, 179, 403. Academic Press Inc. |
| ISSN: | 1095-9572 1053-8119 |
| Popis: | Current theories of pre-attentive deviant detection postulate that before the Superior Temporal Cortex (STC) detects a change, the Inferior Frontal Cortex (IFC) engages in stimulus analysis, which is particularly critical for ambiguous deviations (e.g., deviant preceded by a short train of standards). These theories rest on the assumption that IFC and STC are functionally connected, which has only been supported by correlational brain imaging studies. We examined this functional connectivity assumption by applying Transcranial Magnetic Stimulation (TMS) to disrupt IFC function, while measuring the later STC mismatch response with the event-related optical signal (EROS). EROS can localize brain activity in both spatial and temporal dimensions via measurement of optical property changes associated with neuronal activity, and is inert to the electromagnetic interference produced by TMS. Specifically, the STC mismatch response at 120–180 ms elicited by a deviant preceded by a short standard train when IFC TMS was applied at 80 ms was compared with the STC mismatch responses in temporal control (TMS with 200 ms delay), spatial control (sham TMS at vertex), auditory control (TMS pulse noise only), and cognitive control (deviant preceded by a long standard train) conditions. The STC mismatch response to deviants preceded by the short train was abolished by TMS of the IFC at 80 ms, while the STC responses remained intact in all other control conditions. These results confirm the involvement of the IFC in the STC mismatch response and support a functional connection between IFC and STC. |
| Databáze: | OpenAIRE |
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