Urinary Catecholamines in Attention-Deficit Hyperactivity Disorder with and without Comorbid Anxiety
| Autor: | Jeanette Baker, Steven R. Pliszka, Graham A. Rogeness, James W. Maas, Martin A. Javors |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Adrenergic Personality Assessment Normetanephrine behavioral disciplines and activities Methoxyhydroxyphenylglycol Norepinephrine Vanilmandelic Acid chemistry.chemical_compound Internal medicine mental disorders Developmental and Educational Psychology medicine Humans Attention deficit hyperactivity disorder Child Metanephrine business.industry medicine.disease Anxiety Disorders Psychiatry and Mental health Endocrinology chemistry Attention Deficit Disorder with Hyperactivity Anxiety Female medicine.symptom Arousal business Anxiety disorder medicine.drug |
| Zdroj: | Journal of the American Academy of Child & Adolescent Psychiatry. 33:1165-1173 |
| ISSN: | 0890-8567 |
| Popis: | Objective To determine whether there are differences in noradrenergic or adrenergic functioning in children with attention-deficit hyperactivity disorder (ADHD) with and without anxiety. Method ADHD children with and without a comorbid overanxious (ANX) disorder were compared to each other and to normal controls in terms of 2-hour urinary excretion of norepinephrine (NE), epinephrine (EPI), and their metabolites. All subjects performed a fixed series of mentally stressful tasks during the collection period. Results Children with ADHD, regardless of comorbid anxiety, excreted more normetanephrine (NMN), the chief extracellular metabolite of NE, than controls, as well as more vanillyimandelic acid. Children with ADHD alone had lower NE/NMN and EPI/metanephrine ratios compared to controls. Children with ADHD/ANX excreted more EPI than ADHD children without anxiety. Conclusions Children with ADHD may have a higher tonic activity of the noradrenergic system than controls, while children with comorbid ADHD/ANX may be differentiated from those with ADHD alone by higher adrenergic activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|