Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho
| Autor: | Wei, Zhou, Min-Min, Chen, Hui-Ling, Liu, Zi-Lin, Si, Wen-Hui, Wu, Hong, Jiang, Lin-Xiao, Wang, Nosratola D, Vaziri, Xiao-Fei, An, Ke, Su, Cheng, Chen, Ning-Hua, Tan, Zhi-Hao, Zhang |
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| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Proteasome Endopeptidase Complex Adenine Biotin DNA General Medicine Kidney Fibrosis Artemisinins Transforming Growth Factor beta1 Mice HEK293 Cells Transforming Growth Factor beta Azacitidine Animals Humans Pharmacology (medical) Renal Insufficiency Chronic DNA Modification Methylases Klotho Proteins Ubiquitins beta Catenin Glucuronidase Ureteral Obstruction |
| Zdroj: | Acta Pharmacologica Sinica. 43:2609-2623 |
| ISSN: | 1745-7254 1671-4083 |
| Popis: | Renal fibrosis is an unavoidable end result of all forms of progressive chronic kidney diseases (CKD). Discovery of efficacious drugs against renal fibrosis is in crucial need. In a preliminary study we found that a derivative of artemisinin, dihydroartemisinin (DHA), exerted strong renoprotection, and reversed renal fibrosis in adenine-induced CKD mouse model. In this study we investigated the anti-fibrotic mechanisms of DHA, particularly its specific target in renal cells. Renal fibrosis was induced in mice by unilateral ureteral obstruction (UUO) or oral administration of adenine (80 mg · kg |
| Databáze: | OpenAIRE |
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