Targeting of drugs and vaccines to the gut
| Autor: | S.S. Davis, I.R. Wilding, D.T. O'hagan |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Polymers Administration Oral Delivery problems Drug Delivery Systems Pharmaceutical technology γ scintigraphy medicine Animals Humans Prodrugs Pharmacology (medical) Enteric coated Pharmaceutical sciences Intensive care medicine Pharmacology Vaccines business.industry Oxidation reduction Intestinal Absorption Delayed-Action Preparations Immunology Tablets Enteric-Coated business Digestive System Oxidation-Reduction |
| Zdroj: | Pharmacology & Therapeutics. 62:97-124 |
| ISSN: | 0163-7258 |
| DOI: | 10.1016/0163-7258(94)90006-x |
| Popis: | Targeted delivery to the gastrointestinal tract requires a multi-disciplinary approach to research involving contributions from polymer and material scientists, gastroenterologists, pharmaceutical scientists and technologists. Intestinal delivery is important not only for drugs that act locally, but also for those with systemic activity. In particular, there is considerable interest in the oral delivery of peptides and it is felt that the colon may provide an advantageous absorption site for such molecules. The different targeting mechanisms available to the pharmaceutical scientist to provide site-specific delivery in the gastrointestinal tract will be critically assessed. Delivery systems and targeting agents, which are being developed for the delivery of drugs, may also be exploited for the delivery of vaccines, since many of the delivery problems are common to both areas. Recent developments in the design of oral antigen formulations will be discussed in this review. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|