Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation
| Autor: | J.P. Hugot, J.P. Cezard, Frank M. Ruemmele, N. Moes, Olivier Goulet, Florence Lacaille |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Anemia medicine.medical_treatment Gastroenterology Organ transplantation Tacrolimus Transplantation Immunology hemic and lymphatic diseases Internal medicine medicine Immunology and Allergy Humans Pharmacology (medical) Child Antibacterial agent Transplantation Cytopenia business.industry Immunosuppression medicine.disease Hematologic Diseases Immunology Rituximab Female business medicine.drug |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 6(5 Pt 1) |
| ISSN: | 1600-6135 |
| Popis: | Rare cases of dysimmune phenomena after solid organ transplantation were described in the past. In the present series, we describe six children who developed severe dysimmune anemia or thrombocytopenia while treated with tacrolimus after liver or small bowel transplantation. All patients were off steroids or under low doses alternate day steroid medication when dysimmune cytopenia developed. All patients had positive anti-platelets antibodies and/or Coombs' positive anemia. Therapy was successful in all six patients with a rapid response to corticosteroids in three children, and to anti-CD20 monoclonal antibodies (rituximab) in the three others. The pathogenesis of these rare dysimmune/autoimmune disorders might be related to the interference of tacrolimus with T-cell functions and/or the endogenous control mechanisms of T-lymphocyte activation and down-regulation. Although rare, these complications must be known when discussing protocols of immunosuppression. |
| Databáze: | OpenAIRE |
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