Bone metastases incidence and its correlation with hormonal and human epidermal growth factor receptor 2 neu receptors in breast cancer

Autor: Veenita Yogi, O P Singh, Pallavi Redhu, Vivek Tiwari, Ananya Pareek, HU Ghori
Rok vydání: 2019
Předmět:
0301 basic medicine
Oncology
Receptor
ErbB-2
Estrogen receptor
0302 clinical medicine
visceral metastases
Prospective Studies
Receptor
Lymph node
Aged
80 and over
medicine.diagnostic_test
Incidence (epidemiology)
Incidence
General Medicine
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
medicine.anatomical_structure
Receptors
Estrogen
030220 oncology & carcinogenesis
Lymphatic Metastasis
Female
Receptors
Progesterone
estrogen receptor
Adult
medicine.medical_specialty
Bone Neoplasms
Breast Neoplasms
lcsh:RC254-282
03 medical and health sciences
Breast cancer
breast cancer
Internal medicine
Progesterone receptor
medicine
Biomarkers
Tumor
Humans
Radiology
Nuclear Medicine and imaging
spine and pelvis
Aged
business.industry
Bone metastases
human epidermal growth factor receptor 2
medicine.disease
030104 developmental biology
Bone scintigraphy
Lymph Nodes
business
Hormone
Zdroj: Journal of Cancer Research and Therapeutics, Vol 15, Iss 5, Pp 971-975 (2019)
ISSN: 1998-4138
Popis: Aim: In this paper, we present a prospective observational study, which determines the incidence of bone metastases and its correlation with hormonal receptors (estrogen receptor [ER]/progesterone receptor [PR]) and human epidermal growth factor receptor 2 (HER2) in breast cancer. Materials and Methods: From October of 2015 to July 2017, 262 patients were eligible for the study, of which 98 patients presented/developed bone metastases. ER/PR and HER2 receptor status were determined, and bone scintigraphy with a technetium-99 m was carried out on each patient during the study. Results: The incidence rate of bone metastases as found in this study was 25.25%, and the mean and median age at diagnosis were 47.23 and 46, respectively (age range = 28–80). Bone metastases were more prevalent in ER-positive tumors (P = 0.043), tumors with lymph node positivity (P = 0.002), and lower grade tumors (P = 0.002), whereas visceral metastases were more common with ER-tumors (P = 0.005), tumors with higher grade (P = 0.012), and tumors with lymph node positivity (P = 0.034). In this study cohort, the spine and pelvis were the most commonly involved subsites of bone metastases (P < 0.001). Conclusion: This study demonstrates that the metastatic patterns in breast cancer strongly correlate with various breast cancer subtypes, mainly designated by ER, PR, and HER2. Hormone receptor-positive tumors show a predilection for bones as the first site of relapse compared to hormone-receptor-negative tumors which have a proclivity to develop as visceral metastases.
Databáze: OpenAIRE
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