Daurichromenic Acid-producing Oxidocyclase in the Young Leaves of Rhododendron dauricum
| Autor: | Yoshinori Asakawa, Jung-Bum Lee, Futoshi Taura, Fumiya Kurosaki, Toshihiro Hashimoto, Miu Iijima |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Daurichromenic acid
Rhododendron medicine.medical_treatment Plant Science Cofactor Catalysis chemistry.chemical_compound Biosynthesis Drug Discovery medicine Chromans Plant Proteins Pharmacology chemistry.chemical_classification Rhododendron dauricum ATP synthase biology Chemistry General Medicine biology.organism_classification Biosynthetic Pathways Plant Leaves Enzyme Complementary and alternative medicine Biochemistry biology.protein Cannabinoid |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x1400900928 |
| Popis: | Rhododendron dauricum L., a flowering tree popular in Hokkaido, produces daurichromenic acid (DCA), a terpenophenol with a potent anti-HIV activity. The DCA-producing enzyme, named DCA synthase, could be detected in the soluble protein fraction prepared from the young leaves of R. dauricum. DCA synthase catalyzed oxidocyclization of the farnesyl group of grifolic acid to form (+)-DCA as the major reaction product. The DCA synthase reaction proceeds without the need for any cofactors and coenzymes except for molecular oxygen. Interestingly, these catalytic properties of DCA synthase are quite similar to those reported for cannabinoid synthases in the marijuana plant Cannabis sativa L. |
| Databáze: | OpenAIRE |
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