Polymorphism of μ1-opioid receptor (OPRM1) gene may be of value in genesis of renal malignant neoplasm
| Autor: | A. L. Potapov, A. D. Kaprin, S. A. Ivanov, A. V. Boiarkina, N. Yu. Novikov, R. R. Gevorkyan, I. P. Kostyuk |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures Urology Single-nucleotide polymorphism behavioral disciplines and activities Gastroenterology Renal neoplasm polymorphism 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine medicine Neoplasm Radiology Nuclear Medicine and imaging In patient Allele OPRM1 gene μ1-opioid receptor renal neoplasm business.industry Incidence (epidemiology) medicine.disease 030104 developmental biology nervous system Oncology Nephrology 030220 oncology & carcinogenesis Medicine Surgery business psychological phenomena and processes |
| Zdroj: | Onkourologiâ, Vol 15, Iss 3, Pp 42-45 (2019) |
| ISSN: | 1996-1812 1726-9776 |
| Popis: | Objective: to evaluate alleles distribution of single nucleotide polymorphism 118A>G of μ1-opioid receptor (OPRM1) gene in patients with renal neoplasm and benign diseases.Materials and methods. 100 consecutive patients after renal surgeries retrospectively divided into groups with neoplasm (n = 29) and benign diseases (n = 71).Results. The incidence of renal neoplasm was much higher in homozygous 118A patients than in AG + GG group (36.4 % vs. 14.7 %; p = 0.035).Conclusion. Single nucleotide polymorphism 118A>G OPRM1 gene may be of value in genesis of renal neoplasm. |
| Databáze: | OpenAIRE |
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