Impact of microarousal associated with increased negative esophageal pressure in sleep-disordered breathing
| Autor: | Akiko Noda, Mayo Sukegawa, Seiko Miyata, Yoshinari Yasuda, Yoshinori Hasegawa, Yasuo Koike, Tatsuki Sugiura, Seiichi Nakata, Kumiko Honda, Tsutomu Nakashima |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Neurology Manometry Polysomnography medicine.medical_treatment Positive pressure Arousal Esophagus medicine Humans Circadian rhythm Continuous positive airway pressure Work of Breathing Sleep Apnea Obstructive Sleep disorder Continuous Positive Airway Pressure medicine.diagnostic_test business.industry Sleep apnea Middle Aged medicine.disease Otorhinolaryngology Anesthesia Female Sleep Stages Neurology (clinical) business |
| Zdroj: | Sleep and Breathing. 13:369-373 |
| ISSN: | 1522-1709 1520-9512 |
| Popis: | "Microarousals" during sleep have not been analyzed systematically. We investigated the importance of "microarousals" (lasting 1.5-3 s).Standard polysomnography including esophageal pressure (Pes) assessment was performed on ten patients (aged 54.0 +/- 5.0 years) with respiratory effort-related arousalor =5/h. We measured the number of arousals per hour (American Sleep Disorders Association (ASDA) arousal index) and the number of microarousals lasting 1.5-3 s per hour (mASDA arousal index). On the night after the baseline sleep study, we performed overnight continuous positive airway pressure (CPAP) titration.mASDA arousals, characterized by lower Pes values, were observed more frequently in patients with sleep-disordered breathing. The Pes results did not differ significantly between ASDA and mASDA arousals (-15.6 +/- -5.0 vs -15.0 +/- -4.4 cmH(2)O). mASDA arousals were significantly improved by CPAP treatment (mASDA arousals, 82.6 +/- 60.1 vs 6.0 +/- 1.4/h).mASDA arousals were characterized by an increase in Pes. mASDA arousals are thus key to our understanding of clinical manifestations in patients with sleep-disordered breathing. |
| Databáze: | OpenAIRE |
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