Unusual cases of resistance to minoxidil therapy
| Autor: | James O. Wells |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Drug
Adult Guanethidine Male medicine.medical_specialty media_common.quotation_subject Drug Resistance Hemodynamics Vasodilation Blood Pressure Obstructive cardiomyopathy Cardiovascular System Catecholamines Refractory Internal medicine Renin medicine Humans media_common Aged Pharmacology business.industry Cardiomyopathy Hypertrophic Dermatology Pyrimidines Minoxidil Hypertension Cardiology Female Cardiology and Cardiovascular Medicine business Gastrointestinal Motility Trimethaphan medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 2 |
| ISSN: | 0160-2446 |
| Popis: | Minoxidil was used to treat 112 patients with severe and refractory hypertension during a period of 8 years. The drug was highly effective and resistant cases were distinctly unusual. We reported here 4 such cases. In 2, the patients showed no response to large doses, even when minoxidil was combined with other drugs. In the third, a patient with severe gastrointestinal abnormalities could not retain the drug. No proof exists that if it had been given parenterally it would not have been effective. The last case is of a patient with obstructive cardiomyopathy (IHSS) who reponded well to minoxidil. Because of the vasodilator's profound effect on the cardiovascular system, changes in this patient's hemodynamics occurred which made fluid retention and cardiomegaly intolerable. Patients with severe obstructive cardiomyopathy should be considered for therapy with a strong vasodilator only with caution and with the awareness that fluid retention may be disproportionately large. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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