Soluble PECAM-1, but Not P-Selectin, Nor Osteonectin Identify Acute Myocardial Infarction in Patients Presenting with Chest Pain
| Autor: | Victor L. Serebruany, Anitha Pothula, Selva R. Murugesan, Paul A. Gurbel, Husam B. Semaan |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Thorax Chest Pain medicine.medical_specialty P-selectin Myocardial Infarction Chest pain Gastroenterology Diagnosis Differential Predictive Value of Tests Internal medicine medicine Humans Osteonectin Pharmacology (medical) Platelet Prospective Studies Myocardial infarction Aged biology Cell adhesion molecule business.industry Middle Aged musculoskeletal system medicine.disease Platelet Endothelial Cell Adhesion Molecule-1 Endothelial stem cell P-Selectin Immunology biology.protein Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Cardiology. 91:50-55 |
| ISSN: | 1421-9751 0008-6312 |
| DOI: | 10.1159/000006876 |
| Popis: | We sought to determine plasma levels of platelet/endothelial cell adhesion molecule-1 (PECAM-1), P-selectin, and platelet-derived osteonectin, and prospectively compare these data with the discharge diagnosis in patients presenting with chest pain in a community hospital Emergency Department. Soluble antigens were measured by ELISA in 44 subjects including patients with acute myocardial infarction (AMI) (n = 13), chest pain of noncardiac origin (n = 17), and compared to those of age- and sex-matched healthy controls (n = 14). Elevated soluble PECAM-1 (64.5 ± 18.3 ng/ml, p = 0.019), but not P-selectin (149.5 ± 49.8 ng/ml, p = NS), nor osteonectin (549.5 ± 159.1 ng/ml, p = NS), occurred in the AMI group as compared to patients with noncardiac chest pain (46.2 ± 7.5 ng/ml, 118.2 ± 40.1 ng/ml, and 619.4 ± 74.4 ng/ml, respectively). Increased plasma PECAM-1 may serve as a useful marker in the early detection of patients with AMI. Larger studies will be necessary to confirm the utility of soluble PECAM-1 in identifying AMI among patients presenting with chest pain. |
| Databáze: | OpenAIRE |
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