Mirtazapine-induced steatosis
| Autor: | Elin Thomas, Aled Lloyd, Chin Lye Ch'ng, Namor Williams, Hasan Haboubi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Biopsy Mirtazapine Peripheral edema Jaundice 02 engineering and technology Mianserin Antidepressive Agents Tricyclic Gastroenterology Lethargy Liver Function Tests Internal medicine 0202 electrical engineering electronic engineering information engineering medicine Humans Pharmacology (medical) 060201 languages & linguistics Pharmacology medicine.diagnostic_test business.industry Fatty liver 06 humanities and the arts Adrenergic alpha-2 Receptor Antagonists Middle Aged medicine.disease Fatty Liver Liver 0602 languages and literature 020201 artificial intelligence & image processing Female Liver function Steatosis medicine.symptom Chemical and Drug Induced Liver Injury Liver function tests business medicine.drug |
| Zdroj: | International journal of clinical pharmacology and therapeutics. 55(7) |
| ISSN: | 0946-1965 |
| Popis: | Mirtazapine is a commonly used drug indicated for the treatment of severe depression. It works as a presynaptic αsub2/sub-adrenoreceptor antagonist that increases central noradrenergic and serotonergic neurotransmission, and it is metabolized by the p450 cytochrome oxidase system. There is evidence within the literature to suggest a link between antidepressants and increased liver enzymes, although case reports demonstrating a link between mirtazapine specifically and steatosis are sparse. Here, we present a case of mirtazapine-induced steatosis in a 48-year-old office worker. She presented with painless jaundice of 2 days duration and generalized lethargy and peripheral edema present for 3 weeks beforehand. Extensive investigations were undertaken to identify the cause of her jaundice but no biochemical, blood-borne, or anatomical cause could be found. Mirtazapine was subsequently stopped, and her liver function, both clinically and biochemically, improved rapidly. She made a full recovery after discontinuation of her mirtazapine. . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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