ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia
| Autor: | Diogo R. Lara, Maria Isabel Melaragno, Fernanda Teixeira da Silva Bellucco, Rodrigo A. Bressan, Ary Gadelha, Denise Maria Christofolini, Jair de Jesus Mari, Gustavo L. Ottoni, Vanessa Kiyomi Ota, Marília de Arruda Cardoso Smith, Sintia Iole Belangero, Idaiane Assunção, Andrea Parolin Jackowski, Airton F. Santos-Filho, Marcos L. Santoro |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Genotype Polymorphism Single Nucleotide Brain mri medicine Image Processing Computer-Assisted Humans Genetic Predisposition to Disease Biological Psychiatry Aged Cerebral Cortex Analysis of Variance Membrane Proteins Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Frontal lobe Schizophrenia Brain size Female Psychology Neuroscience Acyltransferases |
| Zdroj: | Schizophrenia research. 145(1-3) |
| ISSN: | 1573-2509 |
| Popis: | ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes. |
| Databáze: | OpenAIRE |
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