Structural and Functional Changes in Pulmonary Macrophages and Lungs of Mice Infected with Influenza Virus A/H5N1 A/goose/Krasnoozerskoye/627/05
| Autor: | Alexander Shestopalov, A. G. Anikina, L. A. Cherdanceva, A. V. Kovner, V. A. Shkurupy, O. V. Potapova, T. V. Sharkova |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Fas-Associated Death Domain Protein Nitric Oxide Synthase Type II medicine.disease_cause Cathepsin D General Biochemistry Genetics and Molecular Biology Virus TNF-Related Apoptosis-Inducing Ligand Mice chemistry.chemical_compound Goose Orthomyxoviridae Infections Fibrosis biology.animal Macrophages Alveolar Animals Medicine Lung Peroxidase Cathepsin Influenza A Virus H5N1 Subtype biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry General Medicine medicine.disease Influenza A virus subtype H5N1 Mice Inbred C57BL Disease Models Animal chemistry Myeloperoxidase Immunology biology.protein Muramidase Nasal administration Lysozyme business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 153:229-232 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-012-1683-y |
| Popis: | C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fibrosis of the interstitium. On days 6-10 after infection, fibrosis was found in the zones of postnecrotic inflammatory infiltration. The expression of lysozyme and myeloperoxidase by pulmonary macrophages was initially increased, but decreased on day 10 of the study. The number of cathepsin D-expressing macrophages was elevated up to the 10th day of examination. |
| Databáze: | OpenAIRE |
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