Supplementary Figures from IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors

Autor: Tomasz Skorski, Italo Tempera, Mariusz A. Wasik, Katarzyna Piwocka, Huaqing Zhao, Lena N. Lupey-Green, Margaret Nieborowska-Skorska, Daniel Gritsyuk, Michael Hulse, Yashodhara Dasgupta, Reza Nejati, Samantha K. Langer, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kayla Martin, Silvia Maifrede
Rok vydání: 2023
DOI: 10.1158/1541-7786.22510833
Popis: Supplementary Figure S1. BL #1 cells display low HR activity. Supplementary Figure S2. BL #1 induced BL-like leukemia in NSG mice Supplementary Figure S3. IGH/MYC-positive cells are hypersensitive to RAD52 inhibitor. Supplementary Figure S4. IGH/MYC does not downregulate mRNA encoding BRCA2. Supplementary Figure S5. c-MYC regulates the expression of BRCA2 protein. Supplementary Figure S6. miR-1245 is upregulated in IGH/MYC-positive cells.
Databáze: OpenAIRE