Intestinal Epithelial Autophagy Is Essential for Host Defense against Invasive Bacteria
| Autor: | Rhea Sumpter, Beth Levine, Jamaal L. Benjamin, Lora V. Hooper |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Salmonella typhimurium
Cancer Research medicine.disease_cause Microbiology Mice 03 medical and health sciences 0302 clinical medicine Immunity Immunology and Microbiology(all) Virology Autophagy Enterococcus faecalis medicine Animals Intestinal Mucosa Molecular Biology Pathogen Gram-Positive Bacterial Infections 030304 developmental biology Salmonella Infections Animal 0303 health sciences Innate immune system biology Epithelial Cells Pathogenic bacteria biology.organism_classification Intestinal epithelium Immunity Innate Epithelium Disease Models Animal medicine.anatomical_structure 030220 oncology & carcinogenesis Parasitology Bacteria |
| Zdroj: | Cell Host & Microbe. 13:723-734 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2013.05.004 |
| Popis: | SummaryThe mammalian intestine is colonized with a diverse community of bacteria that perform many beneficial functions but can threaten host health upon tissue invasion. Epithelial cell-intrinsic innate immune responses are essential to limit the invasion of both commensal and pathogenic bacteria and maintain beneficial host-bacterial relationships; however, little is known about the role of various cellular processes, notably autophagy, in controlling bacterial interactions with the intestinal epithelium in vivo. We demonstrate that intestinal epithelial cell autophagy protects against tissue invasion by both opportunistically invasive commensals and the invasive intestinal pathogen Salmonella Typhimurium. Autophagy is activated following bacterial invasion of epithelial cells through a process requiring epithelial cell-intrinsic signaling via the innate immune adaptor protein MyD88. Additionally, mice deficient in intestinal epithelial cell autophagy exhibit increased dissemination of invasive bacteria to extraintestinal sites. Thus, autophagy is an important epithelial cell-autonomous mechanism of antibacterial defense that protects against dissemination of intestinal bacteria. |
| Databáze: | OpenAIRE |
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