Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions
| Autor: | Gregory S. Smith, Sharon Prince, Alan T. Hutton, Irwin Cassells, Tameryn Stringer |
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| Rok vydání: | 2018 |
| Předmět: |
Denticity
chemistry.chemical_element 010402 general chemistry Crystallography X-Ray Iridium 01 natural sciences Biochemistry Medicinal chemistry Ruthenium Rhodium Inorganic Chemistry Metal Organometallic Compounds Humans Cytotoxicity 010405 organic chemistry Ligand Spectrum Analysis Solvation DNA 0104 chemical sciences chemistry visual_art visual_art.visual_art_medium MCF-7 Cells |
| Zdroj: | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 23(5) |
| ISSN: | 1432-1327 |
| Popis: | A series of bidentate salicylaldimine ligands was prepared and reacted with either [RuCl(µ-Cl)(p-cymene)]2, [RhCl(µ-Cl)(Cp*)]2 or [IrCl(µ-Cl)(Cp*)]2. All of the compounds were characterised using an array of spectroscopic and analytical techniques, namely, nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy and mass spectrometry. Single crystal X-ray diffraction (XRD) was used to confirm the bidentate coordination mode of the salicylaldimine ligand to the metal centre. The platinum group metal (PGM) complexes were screened against the MCF7 breast cancer cell line. The ruthenium and iridium salicylaldimine complexes showed comparable or greater cytotoxicity than cisplatin against the MCF7 cancer cells, as well as greater cytotoxicity than their rhodium counterparts. Three of the salicylaldimine complexes showed potent activity in the range 18–21 µM. Two of these complexes had a greater affinity for cancerous cells than for CHO non-cancerous cells (SI > 4). Preliminary mechanistic studies suggest that the ruthenium complexes undergo solvation prior to 5′-GMP binding, whereas the iridium complexes were inert to the solvation process. |
| Databáze: | OpenAIRE |
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