A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties
| Autor: | Taralee Hamner, Nancy Raitano Lee, Elizabeth I. Adeyemi, Liv S. Clasen, Megan Perez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Neural correlates of consciousness Down syndrome medicine.diagnostic_test 05 social sciences Brain morphometry Sleep apnea Magnetic resonance imaging Audiology medicine.disease Sleep in non-human animals Comorbidity Article 03 medical and health sciences Clinical Psychology Frontal lobe Developmental and Educational Psychology medicine 0501 psychology and cognitive sciences 0305 other medical science Psychology 050104 developmental & child psychology |
| Zdroj: | Res Dev Disabil |
| ISSN: | 0891-4222 |
| Popis: | Background Down syndrome is associated with poor sleep but little is known about its neural correlates. Aims The current research compared brain morphometry in youth with Down syndrome with parent-reported sleep problems (DS-S) to peers with Down syndrome (DS) and typical development (TD) without parent-reported sleep problems matched on age (M = 15.15) and sex ratio (62 % female). Methods and procedures Magnetic resonance imaging was completed on a 3 T scanner. Participants were stratified into groups based on parent-report: DS-S (n = 17), DS (n = 9), TD (n = 22). Brain morphometry, processed with the FreeSurfer Image Analysis Suite, was compared across groups. In addition, the co-occurrence of medical conditions in the DS groups was examined. Outcomes and results Youth with DS-S had reduced total, frontal, parietal, and temporal brain volumes relative to DS and TD peers. They also had higher rates of congenital heart defects than the DS-only group; however, this comorbidity did not appear to account for morphometry differences. Conclusions and implications Parent-reported sleep problems in DS appear to relate to global and localized volume reductions. These preliminary results have implications for understanding the neural correlates of poor sleep in DS; they also highlight the importance of examining relations between sleep and other medical comorbidities. |
| Databáze: | OpenAIRE |
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