Lower Respiratory Tract Infection and Genus Enterovirus in Children Requiring Intensive Care: Clinical Manifestations and Impact of Viral Co-Infections
| Autor: | Desiree Henares, Mariona-Fernández de-Sevilla, Pedro Brotons, Carmen Muñoz-Almagro, Iolanda Jordan, María Cabrerizo, Jon González-de-Audicana, Cristina Esteva, Silvia Ricart, Cristian Launes, Georgina Armero, Daniel Penela-Sánchez |
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| Přispěvatelé: | Instituto de Salud Carlos III, Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica |
| Rok vydání: | 2021 |
| Předmět: |
Male
Critical Care Rhinovirus intensive care units medicine.disease_cause Microbiology Asymptomatic Article Virus Lower respiratory tract infection co-infection Virology Intensive care Enterovirus Infections medicine Humans Respiratory system Child Respiratory Tract Infections Enterovirus Enterovirus D Human child Intensive care units Coinfection enterovirus business.industry Infant Newborn Infant medicine.disease QR1-502 Co-infection Hospitalization rhinovirus Infectious Diseases Child Preschool Respiratory Syncytial Virus Human lower respiratory tract infection Respiratory virus Female medicine.symptom business |
| Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) Viruses Volume 13 Issue 10 Viruses, Vol 13, Iss 2059, p 2059 (2021) |
| Popis: | Infection by rhinovirus (RV) and enterovirus (EV) in children ranges from asymptomatic infection to severe lower respiratory tract infection (LRTI). This cohort study evaluates the clinical impact of RV/EV species, alone or in codetection with other viruses, in young children with severe LRTI. Seventy-one patients aged less than 5 years and admitted to the Paediatric Intensive Care Unit (PICU) of a reference children's hospital with RV or EV (RV/EV) LRTI were prospectively included from 1/2018 to 3/2020. A commercial PCR assay for multiple respiratory pathogens was performed in respiratory specimens. In 22/71, RV/EV + respiratory syncytial virus (RSV) was found, and 18/71 had RV/EV + multiple viral detections. Patients with single RV/EV detection required invasive mechanical ventilation (IMV) as frequently as those with RSV codetection, whereas none of those with multiple viral codetections required IMV. Species were determined in 60 samples, 58 being RV. No EV-A, EV-C, or EV-D68 were detected. RV-B and EV-B were only found in patients with other respiratory virus codetections. There were not any associations between RV/EV species and severity outcomes. To conclude, RV/EV detection alone was observed in young children with severe disease, while multiple viral codetections may result in reduced clinical severity. Differences in pathogenicity between RV and EV species could not be drawn. This project is supported by the Spanish National Health Institute Carlos III (Grant id. PI17/349). DH received a grant for predoctoral training in research into Health by the Spanish National Health Institute Carlos III (project number: FI17/00248). DH also received a grant from Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) for a research stay. The funders have not influenced the design or analysis, nor have they had any role in preparing the manuscript. Sí |
| Databáze: | OpenAIRE |
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