Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
| Autor: | Pippa Corrie, George Carnell, Jonathan L. Heeney, Rainer Döffinger, David M Favara, M. L. Ceron-Gutierrez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
2019-20 coronavirus outbreak Letter Epidemiology IgG Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses 030106 microbiology Immunology breastmilk Plasma protein binding Breast milk Microbiology Serum antibody 03 medical and health sciences Antigen Virology antibody Drug Discovery Medicine skin and connective tissue diseases biology business.industry SARS-CoV-2 fungi COVID-19 General Medicine respiratory tract diseases Heat inactivation body regions 030104 developmental biology Infectious Diseases biology.protein Parasitology Antibody business IgA |
| Zdroj: | Emerging Microbes & Infections article-version (VoR) Version of Record |
| ISSN: | 2222-1751 |
| Popis: | A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS-CoV-2 neutralizing antibodies. Holder breast milk pasteurization did not diminish SARS-CoV-2 antibody titres but it reduced its neutralizing capacity, while serum heat inactivation had no negative effect on SARS-CoV-2 serum antibody levels and neutralizing capacity. Current data on SARS-CoV-2 and breastmilk are reviewed. |
| Databáze: | OpenAIRE |
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