Effectiveness of melatonin to restore fish brain activity in face of permethrin induced toxicity
| Autor: | Debjit Das, Suman Chakraborty, Mahammed Moniruzzaman, Mainak Mukherjee |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
010504 meteorology & atmospheric sciences Health Toxicology and Mutagenesis Exogenous melatonin 010501 environmental sciences Biology Toxicology 01 natural sciences Melatonin receptor Antioxidants Melatonin Malondialdehyde Internal medicine parasitic diseases medicine Animals Permethrin 0105 earth and related environmental sciences chemistry.chemical_classification Superoxide Dismutase Brain General Medicine Glutathione Pollution Hsp70 Oxidative Stress Enzyme Endocrinology chemistry Toxicity Fish Female medicine.drug |
| Zdroj: | Environmental Pollution. 266:115230 |
| ISSN: | 0269-7491 |
| Popis: | Present study demonstrates permethrin induced oxidative damage in fish brain and explores effectiveness of melatonin to ameliorate brain function. Adult female Notopterus notopterus were exposed to nominal permethrin concentrations at 1/20th (0.34 μg/l) and 1/10th (0.68 μg/l) of LC50 for 15 days. The measured permethrin concentrations using gas chromatography (GC-ECD) were 0.28 μg/l and 0.57 μg/l, respectively. Some fish were sacrificed to collect brain tissue after 15 days of exposure. Remaining fish from both groups were administered exogenous melatonin (50 μg/kg, 100 μg/kg body weight) for 7 days and brain tissues were collected. Brain enzymes, ntioxidant factors, HSP70, HSP90, nuclear factor-kappa binding (NFkB), melatonin receptor (MT1R) proteins were measured. Permethrin treatment significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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